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Dr. Moncef Slaoui, former GlaxoSmithKline Chairman of Vaccines, Appointed to SutroVax Board of Directors

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Foster City, CA, July 19, 2017SutroVax, a biopharmaceutical company dedicated to the delivery of best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent serious infectious diseases, today announced the appointment of Moncef Slaoui, PhD, to the company’s Board of Directors. Dr. Slaoui recently retired following a nearly 30-year career at GlaxoSmithKline, during which time he oversaw research and development as Chairman of GSK R&D, served on the board, and most recently built the GSK vaccine division into the lead position in the industry as the Chairman of GSK Vaccines.

“Dr. Slaoui is a distinguished leader, innovator and veteran in the field of vaccine development and we are immensely pleased to have him join our Board,” said Grant Pickering, CEO of SutroVax. “His experience and guidance will be vital as we advance our lead pneumococcal conjugate vaccine candidate into the clinic and expand our R&D, clinical development and manufacturing organizations.”

SutroVax’s broad-spectrum pneumococcal conjugate vaccine (PCV) is designed to provide expanded protection against circulating strains of pneumococcus and has the potential to replace the current vaccines used in infants and adults. SutroVax has generated pre-clinical proof-of-concept in head-to-head studies with its broad-spectrum PCV compared to current vaccines using well accepted immunological endpoints.

“I have been very impressed by SutroVax’s progress with its lead PCV program and its potential to transform the standard of care.  The Company’s differentiated vaccine technology platform has the potential to deliver an array of new vaccine product candidates. I am delighted to be joining SutroVax at this exciting time,” said Dr. Slaoui.

During Dr. Slaoui’s tenure at GSK, he was instrumental in reorganizing the company’s R&D structure to facilitate innovation and improve productivity. He was directly involved in the discovery, development and oversight of GSK’s vaccine pipeline, which was the most productive source of vaccines in the industry — yielding 14 new vaccines in the past decade and assembling the broadest portfolio of vaccines (48), of any company, with nearly a billion doses distributed annually.

Dr. Slaoui received a PhD in Molecular Biology and Immunology from the Université Libre de Bruxelles, Belgium, and completed postdoctoral studies at Harvard Medical School and Tufts University School of Medicine, Boston. He was a professor of Immunology at the University of Mons, Belgium and is a member of the advisory board of the Qatar Foundation and on the board of the International AIDS Vaccine Initiative.

About SutroVax

SutroVax is an independent vaccine platform and development company whose mission is to deliver best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent serious infectious diseases. SutroVax conjugate vaccines are developed utilizing the Company’s exclusive rights to Sutro Biopharma’s Xpress CF Platform, a cell-free protein synthesis technology. The platform represents a major advancement over conventional conjugate vaccine production methods, by enabling precise and consistent conjugation of antigens to site-specific locations on a protein carrier that do not impede T-cell help resulting in higher-potency conjugates. SutroVax is utilizing these more potent conjugates to develop a broader-spectrum PCV product. For more information, visit www.sutrovax.com.

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Contact:
Julie Rathbun
Rathbun Communications
206-769-9219
julie@rathbuncomm.com

SutroVax Announces Closing of $64M via Series B Financing

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  • Announces achievement of pre-clinical proof-of-concept with lead program: Potential best-in-class pneumococcal conjugate vaccine
  • Advancing lead into IND-enabling development to obtain clinical proof-of-concept

Foster City, CA, March 21, 2017SutroVax, a biopharmaceutical company dedicated to the delivery of best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent serious infectious diseases, today announced the closing of a $60 million Series B financing. The financing was led by new investors Frazier Healthcare Partners and Pivotal bioVenture Partners, and included participation from all existing investors: Abingworth, Longitude Capital, Roche Venture Fund and CTI Life Sciences Fund. In addition to Series B funds raised, the Company’s existing investors are investing an additional $4 million in SutroVax.

SutroVax will use the proceeds from this financing to advance its lead pneumococcal conjugate vaccine (PCV), which prevents invasive pneumococcal disease caused by Streptococcus pneumoniae, and accelerate the Company’s antigen discovery and early-stage development efforts in other disease areas. SutroVax’s broad-spectrum PCV is designed to provide expanded protection against circulating strains of pneumococcus and has the potential to replace the current vaccines used in infants and adults. SutroVax has generated pre-clinical proof-of-concept in head-to-head studies with its broad-spectrum PCV compared to current vaccines using well accepted immunological endpoints.

“The closing of this round, which was highly competitive and oversubscribed, is an important milestone for SutroVax and reflects the significant achievements we have made in developing a pneumococcal conjugate vaccine product candidate with the potential to disrupt a market with annual sales of over $7 billion,” said Grant Pickering, CEO of SutroVax. “This financing enables us to advance our lead PCV program into the clinic and expand our R&D, clinical development and manufacturing organizations.”

SutroVax conjugate vaccines are developed utilizing the Company’s exclusive rights to Sutro Biopharma’s Xpress CF Platform, a cell-free protein synthesis technology. The platform represents a major advancement over conventional conjugate vaccine production methods, by enabling precise and consistent conjugation of antigens to site-specific locations on a protein carrier that do not impede T-cell help resulting in higher-potency conjugates. SutroVax is utilizing these more potent conjugates to develop a broader-spectrum PCV product.

“Frazier Healthcare Partners has followed SutroVax’s progress since its founding and is delighted to make SutroVax its first vaccine investment,” stated Patrick Heron, Managing General Partner.

Tachi Yamada, M.D., Frazier Venture Partner, former President of the Bill & Melinda Gates Foundation Global Health Program and former head of GlaxoSmithKline and Takeda Pharmaceuticals R&D added, “SutroVax’s lead product candidate and technology platform has the potential to deliver the next generation of vaccines for major infectious diseases including pneumococcal disease.”

“We are pleased to make SutroVax the pioneer investment from Pivotal bioVenture Partners, our recently closed inaugural fund. I am delighted to join with the preeminent group of life sciences investors backing the company,” said Tracy Saxton, Ph.D., Managing Partner. “We are excited by the Company’s differentiated approach and ground-breaking progress in developing a potential best-in-class pneumococcal conjugate vaccine to provide coverage of circulating pathogenic strains outside of the current standard of care.”

As part of the financing, Patrick Heron and Tracy Saxton will join the SutroVax Board of Directors.

About Frazier Healthcare Partners

Founded in 1991, Frazier Healthcare Partners is a leading provider of growth and venture capital to healthcare companies. With nearly $3.0 billion total capital raised, Frazier has invested in over 170 companies, with investment types ranging from company creation and venture capital to buyouts of profitable lower-middle market companies. The firm’s Growth Buyout team invests in healthcare and pharmaceutical services, medical products and related sectors. The Life Sciences team invests in therapeutics and related areas that are addressing unmet medical needs through innovation. Frazier has offices in Seattle, WA and Menlo Park, CA, and invests broadly across the US, Canada, and Europe.

About Pivotal bioVenture Partners

Pivotal bioVenture Partners is a newly launched, San Francisco-based venture capital firm investing in early stage biotechnology companies. Pivotal closed a $300 million fund, and its investment strategy is centered on identifying companies developing differentiated science from discovery to early clinical development with the potential to deliver transformative therapies. The Pivotal team includes experienced life science investors and entrepreneurs with a track record of venture investing and scientific acumen.

About Pneumococcal Disease and the Pneumococcal Vaccine Market

Pneumococcal disease is an infection caused by Streptococcus pneumoniae. This infection can cause a wide range of serious illnesses including pneumonia, meningitis and blood stream infection as well as ear and sinus infections. According to the Centers for Disease Control and Prevention (CDC), an estimated 900,000 Americans suffer from pneumococcal pneumonia each year and up to 400,000 hospitalizations occur in the US.  In addition, about 18,000 older adults die each year from pneumococcal disease in the U.S. The market-leading vaccine is a 13-valent PCV, Prevnar 13®, that has worldwide sales of approximately $6 billion annually yet does not protect against a significant number of circulating strains of pneumococcus causing invasive disease in adults and children. In the U.S., the CDC’s Advisory Committee on Immunization Practices (ACIP) recommends all children aged two months to five years and immunocompromised children aged six years and older be vaccinated with Prevnar 13®.  In addition, the ACIP recommends all adults aged 65 years and older and immunocompromised adults aged 19 years and older be vaccinated with Prevnar 13®and Pneumovax®, a 23-valent non-conjugate vaccine with over $600 million in annual sales.

About SutroVax

SutroVax is an independent vaccine platform and development company whose mission is to deliver best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent serious infectious diseases. The company is leveraging its exclusive license to Sutro Biopharma’s Xpress CF platform to perform cell-free protein synthesis and site-specific conjugation for the field of vaccines. For more information, visit www.sutrovax.com.

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Contact:
Julie Rathbun
Rathbun Communications
206-769-9219
julie@rathbuncomm.com

SutroVax Announces Appointment of Industry Leaders to Executive Team, Board & SAB

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Veteran Investment Banking Advisor Elaine Sun named CFO
Drug Developer and Company Builder Dr. Peter Hirth joins Board of Directors
Preeminent Vaccinologist Dr. Jeffrey Almond joins Scientific Advisory Board

South San Francisco, CA, January 4, 2017 – SutroVax, a biopharmaceutical company dedicated to the delivery of best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent deadly infectious diseases, today announced the appointment of Elaine Sun as Chief Financial Officer and the additions of Peter Hirth, Ph.D., to the company’s Board of Directors and Jeffrey Almond, PhD. FMedSci, to the Scientific Advisory Board.

Ms. Sun is a veteran strategic financial and business advisor with more than two decades of experience in the life sciences industry. Prior to joining SutroVax, she served as Managing Director and head of West Coast health care for Evercore Partners, a leading independent investment banking advisory firm, where she led biotechnology coverage. Prior to Evercore, Ms. Sun was a Managing Director at Merrill Lynch and Co. in the Healthcare Investment Banking Group, advising large-cap pharmaceutical, biotechnology and specialty pharmaceutical companies on a range of strategic and financing transactions. During her investment banking tenure, Ms. Sun advised on M&A and financing transactions representing over $50 billion in aggregate transaction value.  Most recently, Ms. Sun built a successful consulting practice, advising venture-backed companies on a range of strategic, financing, partnering and M&A decisions. Ms. Sun received a B.A. in Economics and Japanese Studies from Wellesley College and an M.B.A. from Harvard Business School.

“Elaine brings a wealth of experience and a track record of closing major financial transactions that will be of great value in her new role at SutroVax as we continue to grow and expand our activities both internally and in partnership with other industry leaders,” said Grant Pickering, CEO of SutroVax.

Dr. Hirth co-founded and led Plexxikon, Inc. as its CEO as it built a novel, structure-guided drug discovery platform that advanced several new chemical entities into the clinic, including Zelboraf, which was FDA approved and led to the company’s 2011 acquisition by Daiichi Sankyo for $935 million. Prior to Plexxikon, Dr. Hirth was President of SUGEN, Inc., where he was instrumental in building the company from its inception as well as advancing several kinase inhibitors through clinical trials, including Sutent, which was FDA approved and led to the company’s 1999 acquisition by Pharmacia & Upjohn, Inc. for $728 million. Prior to SUGEN, Dr. Hirth was Vice President of Research at Boehringer Mannheim where he successfully led the company’s erythropoietin program to approval in 1989, which was sold under the name Recormon. Before moving into industry, Dr. Hirth was a research scientist with the Max Planck Institute following his post-doctoral work at University of California, San Diego and obtaining his Ph.D. in molecular genetics from Heidelberg University, Germany.

“Drs. Almond and Hirth are truly giants in their fields of expertise.  Dr. Hirth’s ability to harness the potential from cutting-edge development platforms at emerging biotechnology organizations to deliver novel drugs to the market will be highly valuable to SutroVax, as we advance our lead program into the clinic,” said Mr. Pickering.  “Dr. Almond helmed both internal and external R&D at Sanofi-Pasteur, one of the world’s leading vaccine companies, for over a decade.  His insights will be fundamental to ensuring that we fully leverage our proprietary platform as we focus on creating and developing potential best-in-class vaccines.”

Dr. Almond is Visiting Professor of Microbiology at the William Dunn School of Pathology, University of Oxford and is an Oxford Martin Fellow with the Oxford Martin Programme on Vaccines.  Before that he  was Vice President and Head of Discovery Research and External R&D at Sanofi Pasteur. His scientific contributions include the first demonstration that a single gene can determine the host range of influenza virus – a finding highly relevant to understanding evolution of new pandemic strains; completion of the genetic map of an avian influenza virus, and the first detailed description of the proteins of Influenza B virus. He has also made major contributions to our understanding of poliovirus and its vaccines. In 1985 as a young academic Dr. Almond won the Fleming Award for outstanding contribution to microbiological research by a young microbiologist in the UK, and the pace and extent of his contributions have not diminished. In his previous role at Sanofi Pasteur, he was responsible for the scientific rationale underpinning approximately 30 vaccine projects covering viruses, bacteria and eukaryotic parasites. He is an elected Fellow of the American Academy of Microbiology and in 1999 was awarded the Ivanovsky Medal for “Contributions to the Development of Virology” by The Scientific Council of Virology of Russian Academy of Medical Sciences. He is a Fellow of the UK Academy of Medical Sciences and has served on numerous scientific committees in the UK and beyond, including the governing body of the Medical Research Council.

“The SutroVax platform is the ideal technological approach to use for precision conjugations to deliver a new quality of vaccines, and it is being built to create an engine for multiple product opportunities,” said Dr. Hirth.

“I am delighted to join SutroVax in their quest to develop new and improved vaccines using their exciting new technology,” said Dr. Almond. “I am hugely impressed by their recognition that vaccine R&D includes building the ability to scale-up and industrialise as well as solving problems at the molecular level with their platform.”

About Conjugate Vaccines

Conjugate vaccines comprise the largest segment of the vaccine industry, with annual sales approaching $10 billion across multiple licensed indications, including pneumococcus, meningitis, and H flu.  By far the largest of those indications is the pneumococcus market, with annual sales of nearly $7 billion. Despite the successes to date, there are not only a significant number of additional bacterial strains that have yet to be incorporated into current conjugate vaccines, but also many infectious diseases that have yet to be addressed using this potent modality.

About Xpress CF

The Xpress CF platform allows for efficient conjugation of antigens to precise positions on carrier proteins via the incorporation of multiple non-native amino acid (nnAA) substitutions to permit click chemistry attachment. This precise and robust technique has been designed to produce homogeneous and consistent vaccines that have the potential to confer important immunological and clinical benefits relative to current conjugate vaccines. Pinpointing the placement of the antigen on the carrier has the potential to improve host immune responses by avoiding the discrete sites on the carrier responsible for T-cell help, which are often impinged by current conjugation methods. Furthermore, the precise optimization of antigen positioning on the carrier protein allows the attachment of multiple antigenic constructs to a single protein carrier, which will facilitate the production of broader spectrum vaccines. These improvements, along with our high-yield, streamlined and industrialized production process, have the potential to deliver best-in-class conjugate vaccines to the market with heightened immunity and broader protection.

About SutroVax

SutroVax is an independent vaccine platform and development company whose mission is to deliver best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent deadly infectious diseases. The company is leveraging its exclusive license to Sutro Biopharma’s Xpress CF platform to perform cell-free protein synthesis and site-specific conjugation for the field of vaccines. SutroVax is financed by an international syndicate of experienced, blue-chip venture capital and corporate venture investors. For more information, visit www.sutrovax.com.

 

SutroVax Announces Appointment of Paul Sauer as Vice President, Process Development & Manufacturing

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South San Francisco, CA, May 3 2016 – SutroVax, a biopharmaceutical company dedicated to the delivery of best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent deadly infectious diseases, today announced the appointment of Paul Sauer as Vice President, Process Development & Manufacturing.

Mr. Sauer has over 30 years of experience industrializing biologics for numerous biotechnology companies. Prior to joining SutroVax, Mr. Sauer was Vice President of Process Sciences & Manufacturing at Igenica Biotherapeutics, where he initiated the company’s development activities and built its supply chain network for GMP manufacturing of its antibody drug conjugates. Prior to that, he was Senior Director of Process Development at OncoMed Pharmaceuticals, where he contributed to multiple IND filings.  He also held various process, engineering, scale-up, and manufacturing positions at Protein Design Labs, Scios, and Genentech.  Mr. Sauer has contributed to numerous approved biologics, including Genentech’s Activase® and Pulmozyme®. He also contributed significantly to the development of the patented high-yield process that formed the basis for production of Biogen’s ZinbrytaTM, a humanized antibody whose BLA is currently under FDA review for the treatment of Multiple Sclerosis.

“Paul’s appointment will expedite advancement of our lead conjugate vaccine program as it progresses to clinical development.  His leadership and germane development and scale-up experience will be key additions to our team’s skill set as we solidify our supply chain and proceed to GMP manufacturing,” said Grant Pickering, Chief Executive Officer of SutroVax.

Conjugate vaccines comprise the largest segment of the vaccine industry, with annual sales of over $10 billion across multiple licensed indications, including pneumococcus, meningitis, and H flu.  The largest of these indications is the pneumococcus market, with an annual sales rate of over $7 billion. Despite the successes to date, there are not only a significant number of additional bacterial strains that have yet to be incorporated into current conjugate vaccines, but also many infectious diseases that have yet to be addressed using this potent modality.

“It is unusual for a company at this stage to have access to a mature, industrialized and proprietary platform like Xpress CFTM to leverage for advancement of its development programs. I am pleased to join the SutroVax team as the lead vaccine’s production processes are defined for GMP production,” commented Mr. Sauer.

About Xpress CF

The Xpress CF platform allows for efficient conjugation of antigens to precise positions on carrier proteins via the incorporation of multiple non-natural amino acid (nnAA) substitutions to permit click chemistry attachment. This precise and robust technique results in homogeneous and consistent vaccines that promise to confer important immunological and clinical benefits relative to current conjugate vaccines. Pinpointing the placement of the antigen on the carrier has the potential to improve host immune responses by avoiding the discrete sites on the carrier responsible for T-cell help, which are often impinged by current conjugation methods. Furthermore, the precise optimization of antigen positioning on the carrier protein allows the attachment of multiple antigenic constructs to a single protein carrier, which will facilitate the production of broader spectrum vaccines. These improvements have the potential to deliver best-in-class conjugate vaccines that will have the potential to confer heightened immunity, broader protection and can be both more easily characterized and consistently produced as a result of our high-yield, streamlined and industrialized production process.

About SutroVax

SutroVax is an independent vaccine platform and development company whose mission is to deliver best-in-class conjugate vaccines and novel complex antigen-based vaccines to prevent deadly infectious diseases. The company is leveraging its exclusive license to Sutro Biopharma’s Xpress CF platforms to perform cell-free protein synthesis and site-specific conjugation for the field of vaccines. SutroVax closed its Series A round in 2015 and is financed by an international syndicate of experienced, blue-chip venture capital and corporate venture investors. For more information, visit www.sutrovax.com.

SutroVax raises $22M in Series A

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Vaccine Spin-off from Sutro Biopharma to Utilize Site-Specific Conjugation Technology

South San Francisco, CA, July 23, 2015 – SutroVax, a recently established biopharmaceutical vaccine company, today announced the completion of a $22 million Series A financing. SutroVax is developing vaccines for infectious disease targets, with an initial emphasis on best-in-class conjugate vaccines, using an exclusive license to Sutro Biopharma’s Xpress CF™ and Xpress CF+™ platforms for cell free protein synthesis and site-specific conjugation respectively.

The Series A financing was led by Abingworth, the international investment group, with participation from Longitude Capital, Roche Venture Fund and CTI Life Sciences Fund. SutroVax will use the funds to advance multiple vaccines in its pipeline through pre-clinical proof of concept.

Grant Pickering, CEO of SutroVax said “Our platform technology is already industrialized and uniquely enables precise site-specific conjugation and production of protein antigens that are beyond the reach of current technologies. We intend to develop best-in-class vaccines to address an array of high-impact infectious diseases.”

Conjugate vaccines comprise the largest segment of the vaccine industry with annual sales of approximately $8 billion across multiple licensed indications, including pneumococcus, meningitis, and H flu. By far the largest of those indications is the pneumococcus market with annual sales of nearly $6 billion. Despite the successes to date, there are not only a significant number of additional bacterial strains that have yet to be incorporated into current conjugate vaccines, but also many infectious diseases that have yet to be addressed using this potent modality.

“Abingworth is pleased to work with the talented team at SutroVax and this prestigious group of co-investors” commented Kurt von Emster, Managing Partner of Abingworth.

As part of the financing, Kurt von Emster will become interim Chairman at SutroVax. In addition, Patrick Enright and Dr Tracy Saxton from Longitude Capital and Roche Venture Fund respectively will join Grant Pickering and William Newell, CEO of Sutro Biopharma, on the board of directors.

“It’s gratifying to see another high-value cache of applications gain momentum leveraging the platform and its well-developed infrastructure, including our large-scale cGMP facility,” commented William Newell, CEO of Sutro Biopharma.

About SutroVax: SutroVax is an independent vaccine platform and development company that was spun-out of Sutro Biopharma. The company will leverage Sutro’s Xpress CF and Xpress CF+ platforms for cell-free protein synthesis and site-specific conjugation to develop novel vaccines for an array of disease targets. SutroVax was founded by Grant Pickering, Jeff Fairman Ph.D. (VP Research) and Ash Khanna Ph.D. (Chief Business Officer) and received initial funding from Sutro Biopharma and Johnson & Johnson Innovation.

About Xpress CF+: Xpress CF+ is a proprietary cell-free protein synthesis platform that enables site-specific incorporation of multiple non-natural amino acid substitutions at precisely defined positions in proteins that enable attachment of chemical moieties, including polysaccharide antigens, via click chemistry. Incorporation of non-natural amino acids for conjugation using Xpress CF+ has been applied to antibody drug conjugates and multi-specific antibody-based therapeutics for cancer therapy, including immuno-oncology therapies by Sutro Biopharma. It has also been industrialized to large-scale production under cGMP conditions and has been the subject of multiple major collaborations with select pharmaceutical and biotech companies.